Coenzyme q10
For bipolar and unipolar depression [2], ADHD [3], autism [2], neurodevelopmental disorders [2], and energy in elderly.
Major Depression
SAMe
For depression, improves liver health, osteoarthritis, but l-methylfolate has a similar mechanism and better evidence.
L-methylfolate
[Deplin] Medium effect in depression augmentation [1], may help bipolar depression as well.
Creatine
Augments SSRIs in women only [3]. Improves memory, especially in older adults [2]. Long-COVID [3].
Sarcosine
For depression [3], and positive/negative symptoms of schizophrenia [2], oppositionality in ADHD
l-Theanine
Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3].
Ginkgo
For TD [2], EPS [2], age related cognitive decline [2], GAD [3]. May help vascular depression.
Vitamin B6
Improves mood, PMDD, and treats side effects of lithium/antipsychotics (tremor, hyperprolactin, akathisia, EPS, TD)