Mania Archives - Chris Aiken, MD

Dark-Therapy

Hypnotics, Treatments, Hypnotic for Elderly, Weight Gain, Deepen Sleep, Mania, Mixed, Peripartum Depression, BP Cognition / Chris

Very effective for mania, prevents bipolar, deepens sleep. Mild weight loss.

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Iloperidone

Bipolar, Treatments, Mania, Psychotic symptoms, Mixed, Schizophrenia / Nancy Brandon

[$ Fanapt] Treats mania, unknown effects in depression, not a first-line option.

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Aripiprazole

First line schizophrenia, Major Depression, Bipolar, Treatments, Autism, Treatment Resistant Depression, Tics, Augmentation, Mania, Psychotic Depression, OCD, Psychotic symptoms, Mixed, Prolactinemia, Schizophrenia / Nancy Brandon

[Abilify] Among the better-tolerated antipsychotics, and best-studied for antidepressant
augmentation [1] (but doesn't treat bp-depression). Schizophrenia [1]

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Clozapine

Bipolar, Treatments, Treatment Resistant Schizophrenia, Mania, Mixed, Psychotic symptoms, Negative symptoms, Schizophrenia / Nancy Brandon

[Clozaril] Use in schizophrenia/schizoaffective after 2 failed antipsychotic trials. Prevents suicide
in psychotic disorders.

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Risperidone

Treatments, Autism, Bipolar, Treatment Resistant Depression, PTSD, Mania, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Risperdal] Among most effective antipsychotics for schizophrenia [1]. Mania[3]. Augments
antidepressants in unipolar [3], PTSD [3], OCD [3].

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Asenapine

BP Depression, Bipolar, Treatments, Mania, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Saphris] A good antipsychotic when others aren't tolerated. Treats bipolar mania/mixed [2] and
possibly bp-depression [4].

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Cariprazine

First line schizophrenia, Treatments, BP Depression, Bipolar, First line mania, Treatment Resistant Depression, Mania, Mixed, Psychotic symptoms, Negative symptoms, Schizophrenia / Nancy Brandon

[$ Vraylar] Top for schizophrenia [1] because it improves negative symptoms. Bipolar depression [2] + mania [1], unipolar augmentation [2], but low effect size in depressions.

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Ziprasidone

Bipolar, Treatments, Sleep apnea, Treatment Resistant Depression, Mania, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Geodon] Among best antipsychotics for low weight/diabetes risk. Treats mania/mixed; possibly
helps depression in unipolar and bipolar.

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Olanzapine

Second line schizophrenia, Bipolar, Treatments, Treatment Resistant Schizophrenia, Psychotic Depression, Mania, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Zyprexa] High efficacy in schizophrenia [2], so use before moving to clozapine. Mania [2], augmentation in unipolar [3], PTSD [3].

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Quetiapine

Generalized Anxiety, Treatments, BP Depression, Bipolar, Deepen Sleep, First line mania, Anxiety, Treatment Resistant Depression, OCD, Mania, Mixed, Psychotic symptoms, Anxious Depression, BP Anxiety, Schizophrenia / Nancy Brandon

[Seroquel] Unique antipsychotic – metabolized into an antidepressant so treats unipolar
depression (and GAD) as monotherapy. Top for TRD [1]. Deepens sleep. Tolerability poor, but among the most
effective options for BP-depression [1], BP-anxiety [2], mania, mixed.

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