From pramipexole to probiotics, psychotherapy to neuromodulation, Difficult to Treat Depression covers the latest evidence-based treatments for patients who do not respond to antidepressants. Includes chapters on what doesn’t work (and how to deprescribe), and depressive subtypes that can personalize the treatment: bipolar, psychotic, inflammatory, vascular, trauma-related, peripartum, and seasonal. Available in print and audio.
“An astounding amount of information distilled it into 48 clearly-written chapters… loaded with very practical advice.”
—David Osser, MD, Associate Professor of Psychiatry at Harvard Medical School, author of Psychopharmacology Algorithms
“A source of pragmatic insight and wisdom for any clinician who wrestles with the challenges of… patients who respond suboptimally to traditional monoaminergic antidepressant medications.”
—Joseph F. Goldberg, MD, Clinical Professor of Psychiatry, Icahn School of Medicine, Deputy Editor-in-Chief, The Journal of Clinical Psychiatry, author of Practical Psychopharmacology
An update to the bestseller Why Am I Still Depressed, this book is the ultimate guide for people whose depressions keep coming back. That includes Bipolar II, Recurrent Major Depression, and the full spectrum of moods in between. Covers symptoms, causes, lifestyle tips, natural therapies, medications, and advice for families.
“Perfect book for the patient.” -Robert Post, MD, former Chief, National Institute of Mental Health
This book won’t tell you what to prescribe, but it will tell you how to prescribe it, including:
> How much to raise or lower the dose to adjust for food and drug interactions
> How to personalize prescriptions to fit your patients genetics, age, gender, and ethnicity
> When to use extended release, skin patch, orally disintegrating tablets, and other formulations
“Not only useful, but engaging and entertaining.” -Nassir Ghaemi, MD, Professor, Tufts School of Medicine
Lifestyle hacks for mood disorders. Twenty years ago, I started collecting simple, science-backed steps that improve mental health. This book offers up the 30 best, from blueberries to brisk walking, dawn simulators that improve wakefulness and blue light blockers that help the wakeful fall asleep.
“As a therapist, I use this book with my clients. It’s so empowering and strengths oriented that it’s wonderful to use.” -Amazon Reviewer
Free e-Book on the diet that treats depression
Videos & Webinars
I’ll host the 2-day Mood Disorder Certification Training through PESI April 10-11, 2025
WiseMind seminars on therapy for bipolar disorder
I have several Carlat Psychiatry webinars, and we’ve posted a free one comparing amphetamines to methylphenidate in ADHD.
Underlying Deficits
I talk with PsychoFarm on whether we can treat depression by addressing deficits of folate, omeaga-3, vitamin-D and sunlight
Diet and Depression
Coffee or tea? Blueberries or salmon? All things food-mood with Two Healing Minds
Therapy for Bipolar
A conversation with Richard Hill from the Science of Psychotherapy Podcast
Articles
My Psychiatric Times column covers depression, bipolar, ADHD, and more