ECT
First-line for severe psychotic depression. In other cases of TRD, may prefer over TMS if severe. Also works for bipolar depression.
TMS
One of the most effective therapies for TRD. Well tolerated, improves cognition and neuroplasticity.
Metformin
First-line for antipsychotic weight gain, works best when started early (also prevents DM, dyslipidemia, prolactinemia)
CBD
[Cannabidiol] This “healthier”strain of cannabis is #1 for cannabis use disorder, but questionable in anxiety and insomnia. Watch for drug interactions.
Magnesium
Improves sleep (with melatonin), bruxism, and essential for liver health in alcohol use disorder.
Melatonin
Hypnotic with particular benefits in elderly and children with developmental disorders [1], and antipsychotic weight loss [1].
Pramipexole
[Mirapex] Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome.