Ropinorole(Requip)
Dopaminergic D3 agonist
- Bipolar Depression
- Restless legs
Features
Dosing
2-3mg/night (about twice the target dose of mirapex).
Management
Not as likely to work as pramipexole, but can be used to replace it in those who don’t tolerate pramipexole.
EMR Text
Depression
Ropinorole use based on pilot studies of this dopamine agonist in treatment resistant depression (Cassano P et al, Can J Psychiatry. 2005;50(6):357-360).
Ropinorole’s side effects and risks, including hedonic dysregulation, orthostasis, and hallucinations, reviewed with patient.