Buspirone-melatonin combo
Antidepressant (synergestic effect in low doses)
- Major Depression
- Improves cognition in depression
Features
Dosing
buspirone 15 mg + melatonin 3mg qhs
Management
The two meds have a synergistic effect for depression in low dose, and improved cognition, though this is only based on one trial.
EMR Text
Depression
Low dose buspirone-melatonin combination use based on a randomized controlled trials in depression (Fava M et al, J Psychiatr Res. 2012;46(12):1553-1563).